| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| GREENSVILLE, VA-BRUNSWICK, VA -HSA# 130 | 350 | 101,320 | 345.4 | 340.4 |
| WISE, VA-LEE, VA -HSA# 55 | 766 | 253,560 | 302.1 | 285.1 |
| MERCER, WV-TAZEWELL, VA -HSA# 39 | 1,550 | 534,414 | 290.0 | 267.4 |
| SULLIVAN (KINGSPORT), TN-WASHINGTON, VA -HSA# 151 | 3,071 | 1,049,398 | 292.6 | 257.0 |
| PITTSYLVANIA (DANVILLE), VA-CASWELL, NC -HSA# 132 | 1,181 | 392,010 | 301.3 | 251.5 |
| HALIFAX, VA-MECKLENBURG, VA -HSA# 71 | 675 | 239,805 | 281.5 | 227.9 |
| HENRY, VA-PATRICK, VA -HSA# 79 | 720 | 269,455 | 267.2 | 227.1 |
| ALLEGHANY, VA-GREENBRIER, WV -HSA# 30 | 676 | 231,246 | 292.3 | 223.3 |
| MONTGOMERY, VA-PULASKI, VA -HSA# 70 | 1,022 | 505,301 | 202.3 | 217.1 |
| AUGUSTA, VA-ROCKBRIDGE, VA -HSA# 97 | 958 | 416,536 | 230.0 | 210.3 |
| NEWPORT NEWS CITY, VA-HAMPTON CITY, VA -HSA# 5 | 2,364 | 1,442,579 | 163.9 | 209.8 |
| FREDERICK, VA-BERKELEY, WV -HSA# 25 | 1,820 | 888,293 | 204.9 | 209.7 |
| DINWIDDIE (PETERSBURG), VA-PRINCE GEORGE, VA -HSA# 77 | 765 | 383,386 | 199.5 | 209.2 |
| NORFOLK/PORTSMOUTH CITY, VA-VIRGINIA BEACH CITY, VA -HSA# 6 | 4,859 | 3,277,253 | 148.3 | 207.8 |
| GRAYSON, VA-ALLEGHANY, NC -HSA# 73 | 483 | 181,876 | 265.6 | 190.2 |
| NORTHAMPTON, VA-ACCOMACK, VA -HSA# 137 | 368 | 134,827 | 272.9 | 189.2 |
| ROCKINGHAM, VA-PAGE, VA -HSA# 63 | 746 | 383,497 | 194.5 | 186.1 |
| ROANOKE (ROANOKE), VA-CAMPBELL, VA -HSA# 14 | 3,316 | 1,529,147 | 216.9 | 185.8 |
| SPOTSYLVANIA, VA-CAROLINE, VA -HSA# 135 | 795 | 677,559 | 117.3 | 183.9 |
| HENRICO (RICHMOND), VA-PRINCE EDWARD, VA -HSA# 33 | 5,016 | 2,942,689 | 170.5 | 179.2 |
| ALBEMARLE (CHARLOTTESVILLE), VA-CULPEPER, VA -HSA# 99 | 1,371 | 828,550 | 165.5 | 170.0 |
| PRINCE WILLIAM (DALE CITY), VA-FAUQUIER, VA -HSA# 109 | 716 | 1,046,696 | 68.4 | 156.0 |
| ALEXANDRIA CITY, VA-ARLINGTON - ALEXANDRIA (ARLINGTON), VA -HSA# 69 | 2,919 | 4,104,035 | 71.1 | 112.2 |
