| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| LUZERNE (WILKES-BARRE), PA-COLUMBIA, PA -HSA# 78 | 4,834 | 1,233,412 | 391.9 | 280.7 |
| SCHUYLKILL, PA-MONTOUR, PA -HSA# 8 | 3,615 | 1,028,378 | 351.5 | 268.2 |
| LACKAWANNA (SCRANTON), PA-WAYNE, PA -HSA# 47 | 2,883 | 766,716 | 376.0 | 261.9 |
| ORANGE (NEWBURGH), NY-SULLIVAN, NY -HSA# 86 | 2,879 | 1,306,642 | 220.3 | 255.0 |
| WASHINGTON, PA-FAYETTE, PA -HSA# 100 | 3,717 | 1,178,978 | 315.3 | 245.5 |
| LAWRENCE, PA -HSA# 129 | 963 | 285,849 | 336.9 | 243.0 |
| CATTARAUGUS, NY-MC KEAN, PA -HSA# 35 | 1,719 | 616,999 | 278.6 | 239.3 |
| TIOGA, PA -HSA# 128 | 358 | 124,489 | 287.6 | 237.2 |
| VENANGO, PA-CLARION, PA -HSA# 52 | 895 | 314,942 | 284.2 | 236.0 |
| MAHONING (YOUNG), OH-MERCER, PA -HSA# 345 | 5,228 | 1,819,913 | 287.3 | 235.9 |
| CAMBRIA, PA-BLAIR (ALTOONA), PA -HSA# 57 | 3,890 | 1,253,349 | 310.4 | 235.1 |
| ALLEGHENY (PITTSBURGH), PA-WESTMORELAND, PA -HSA# 42 | 19,440 | 6,513,830 | 298.4 | 232.2 |
| BROOME (BINGHAMTON), NY-BRADFORD, PA -HSA# 19 | 2,914 | 1,084,256 | 268.8 | 225.6 |
| ERIE (ERIE), PA-CHAUTAUQUA, NY -HSA# 106 | 3,509 | 1,388,370 | 252.7 | 223.7 |
| MIFFLIN, PA-HUNTINGDON, PA -HSA# 110 | 867 | 341,138 | 254.1 | 216.0 |
| LYCOMING (WILLIAMSPORT), PA-CLINTON, PA -HSA# 44 | 1,198 | 465,379 | 257.4 | 211.7 |
| CLEARFIELD, PA-CENTRE ( ), PA -HSA# 26 | 1,663 | 778,306 | 213.7 | 211.1 |
| PHILADELPHIA (PHILADELPHIA), PA-MONTGOMERY, PA -HSA# 28 | 25,189 | 11,132,226 | 226.3 | 206.2 |
| DAUPHIN (HARRISBURG), PA-CUMBERLAND, PA -HSA# 43 | 4,252 | 1,845,131 | 230.4 | 205.7 |
| CRAWFORD, PA -HSA# 117 | 648 | 267,780 | 242.0 | 205.6 |
| LEHIGH (ALLE), PA-NORTHAMPTON, PA -HSA# 84 | 5,183 | 2,210,609 | 234.5 | 203.1 |
| FRANKLIN, PA-WASHINGTON (HAGERSTOWN), MD -HSA# 72 | 1,869 | 807,803 | 231.4 | 201.9 |
| ELK, PA -HSA# 125 | 254 | 104,529 | 243.0 | 198.8 |
| YORK (YORK), PA-FREDERICK, MD -HSA# 48 | 3,664 | 1,918,431 | 191.0 | 198.1 |
| LANCASTER (LANCASTER), PA -HSA# 140 | 2,837 | 1,360,658 | 208.5 | 190.2 |
| BERKS (READING), PA -HSA# 139 | 2,451 | 1,061,571 | 230.9 | 189.6 |
