| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| PIKE, KY-LOGAN, WV -HSA# 13 | 1,236 | 438,885 | 281.6 | 321.2 |
| CALLOWAY, KY-CARROLL, TN -HSA# 115 | 1,226 | 323,954 | 378.4 | 295.2 |
| BELL, KY-CLAIBORNE, TN -HSA# 96 | 792 | 281,713 | 281.1 | 285.8 |
| HARRISON, KY-ROBERTSON, KY -HSA# 119 | 191 | 58,485 | 326.6 | 280.8 |
| SCIOTO, OH-ROSS, OH -HSA# 337 | 1,724 | 590,297 | 292.1 | 279.1 |
| FLOYD, KY-JOHNSON, KY -HSA# 11 | 579 | 243,698 | 237.6 | 274.0 |
| MASON, KY-FLEMING, KY -HSA# 116 | 353 | 115,614 | 305.3 | 268.4 |
| OBION, TN-WEAKLEY, TN -HSA# 181 | 705 | 217,388 | 324.3 | 263.7 |
| CUMBERLAND, KY-CLINTON, KY -HSA# 104 | 158 | 48,513 | 325.7 | 263.6 |
| CABELL (HUNTINGTON), WV-BOYD, KY -HSA# 46 | 3,047 | 1,094,505 | 278.4 | 256.8 |
| LETCHER, KY -HSA# 123 | 178 | 79,387 | 224.2 | 250.9 |
| HOPKINS, KY-CHRISTIAN (HOPKINSVILLE), KY -HSA# 45 | 1,591 | 604,310 | 263.3 | 248.1 |
| BARREN, KY-MONROE, KY -HSA# 53 | 621 | 221,662 | 280.2 | 244.1 |
| WHITLEY, KY-LAUREL, KY -HSA# 51 | 917 | 419,585 | 218.5 | 243.7 |
| HENDERSON (HENDERSON), KY-UNION, KY -HSA# 40 | 428 | 182,864 | 234.1 | 238.5 |
| MC CRACKEN, KY-GRAVES, KY -HSA# 12 | 1,830 | 614,053 | 298.0 | 237.3 |
| BOURBON (PARIS), KY-NICHOLAS, KY -HSA# 102 | 192 | 78,875 | 243.4 | 231.3 |
| MADISON, KY-ROCKCASTLE, KY -HSA# 62 | 668 | 328,387 | 203.4 | 223.8 |
| WARREN, KY-LOGAN, KY -HSA# 29 | 1,070 | 503,686 | 212.4 | 222.8 |
| FAYETTE (LEXINGTON-FAYETTE), KY-PERRY, KY -HSA# 18 | 2,581 | 1,413,661 | 182.6 | 219.2 |
| KENTON (COVINGTON), KY-CAMPBELL, KY -HSA# 2 | 1,932 | 1,049,784 | 184.0 | 217.5 |
| JEFFERSON (MADISON), IN-DEARBORN, IN -HSA# 321 | 859 | 407,117 | 211.0 | 215.2 |
| DAVIESS (OWENSBORO), KY-OHIO, KY -HSA# 316 | 1,002 | 451,822 | 221.8 | 213.1 |
| MONTGOMERY, KY-BATH, KY -HSA# 131 | 210 | 93,350 | 225.0 | 208.9 |
| HARDIN, KY-GRAYSON, KY -HSA# 89 | 865 | 514,370 | 168.2 | 208.3 |
| FRANKLIN, KY-OWEN, KY -HSA# 114 | 433 | 223,354 | 193.9 | 207.7 |
| TAYLOR, KY-RUSSELL, KY -HSA# 82 | 463 | 198,254 | 233.5 | 203.6 |
| PULASKI, KY-WAYNE, KY -HSA# 37 | 574 | 273,350 | 210.0 | 201.9 |
| ROWAN, KY-MORGAN, KY -HSA# 67 | 249 | 142,745 | 174.4 | 201.6 |
| JEFFERSON (LOUISVILLE), KY-SHELBY, KY -HSA# 272 | 5,288 | 2,664,864 | 198.4 | 201.2 |
| BOYLE, KY-LINCOLN, KY -HSA# 27 | 630 | 293,131 | 214.9 | 196.4 |
