| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| APPANOOSE, IA-DAVIS, IA -HSA# 649 | 301 | 66,001 | 456.1 | 283.0 |
| LUCAS, IA-WAYNE, IA -HSA# 645 | 236 | 47,508 | 496.8 | 266.7 |
| FLOYD, IA-CHICKASAW, IA -HSA# 634 | 365 | 89,660 | 407.1 | 266.3 |
| CLINTON, IA-WHITESIDE, IL -HSA# 361 | 1,259 | 381,289 | 330.2 | 259.1 |
| POTTAWATTAMIE (COUNCIL BLUFFS), IA-SHELBY, IA -HSA# 596 | 1,435 | 448,686 | 319.8 | 248.2 |
| OBRIEN, IA-OSCEOLA, IA -HSA# 652 | 291 | 65,942 | 441.3 | 242.4 |
| SCOTT (DAVENPORT), IA-MUSCATINE, IA -HSA# 641 | 1,349 | 596,137 | 226.3 | 239.4 |
| POLK (DES MOINES), IA-MARION, IA -HSA# 546 | 4,063 | 1,666,569 | 243.8 | 235.5 |
| MARSHALL, IA-TAMA, IA -HSA# 679 | 562 | 169,323 | 331.9 | 229.9 |
| WOODBURY (SIOUX CITY), IA-BUENA VISTA, IA -HSA# 560 | 1,844 | 629,462 | 292.9 | 229.2 |
| WEBSTER, IA-HUMBOLDT, IA -HSA# 585 | 627 | 174,286 | 359.8 | 228.3 |
| CRAWFORD, IA -HSA# 681 | 159 | 49,358 | 322.1 | 227.1 |
| WAPELLO, IA-MAHASKA, IA -HSA# 589 | 950 | 305,086 | 311.4 | 223.1 |
| CERRO GORDO, IA-KOSSUTH, IA -HSA# 556 | 1,073 | 320,719 | 334.6 | 220.4 |
| BLACK HAWK (WATERLOO), IA-FAYETTE, IA -HSA# 557 | 1,744 | 647,566 | 269.3 | 218.2 |
| LEE, IA-HANCOCK, IL -HSA# 367 | 579 | 201,973 | 286.7 | 215.9 |
| MONTGOMERY, IA-ADAMS, IA -HSA# 647 | 188 | 48,825 | 385.0 | 215.0 |
| CARROLL, IA-CALHOUN, IA -HSA# 633 | 481 | 134,937 | 356.5 | 212.4 |
| MITCHELL, IA -HSA# 665 | 141 | 33,191 | 424.8 | 210.8 |
| DES MOINES, IA-HENRY, IA -HSA# 340 | 572 | 211,988 | 269.8 | 207.1 |
| STORY, IA-HAMILTON, IA -HSA# 606 | 1,163 | 448,466 | 259.3 | 205.9 |
| PAGE, IA-FREMONT, IA -HSA# 644 | 339 | 96,826 | 350.1 | 204.6 |
| POWESHIEK, IA -HSA# 686 | 169 | 56,651 | 298.3 | 201.4 |
| MARTIN, MN-EMMET, IA -HSA# 626 | 330 | 99,301 | 332.3 | 200.7 |
| DUBUQUE (DUBUQUE), IA-STEPHENSON, IL -HSA# 302 | 1,321 | 536,666 | 246.1 | 199.4 |
| CLAY, IA-DICKINSON, IA -HSA# 625 | 396 | 130,880 | 302.6 | 192.8 |
| MINNEHAHA (SIOUX FALLS), SD-LAKE, SD -HSA# 544 | 1,494 | 710,645 | 210.2 | 186.0 |
| CRAWFORD, WI-CLAYTON, IA -HSA# 350 | 391 | 161,255 | 242.5 | 184.8 |
| LINN (CEDAR RAPIDS), IA-JOHNSON, IA -HSA# 545 | 2,204 | 1,184,252 | 186.1 | 184.1 |
| WINNESHIEK, IA -HSA# 395 | 145 | 62,712 | 231.2 | 180.3 |
| LA CROSSE (LA CROSSE), WI-MONROE, WI -HSA# 290 | 1,424 | 684,750 | 208.0 | 176.5 |
| GREENE, IA-GUTHRIE, IA -HSA# 617 | 191 | 64,598 | 295.7 | 170.7 |
| SIOUX, IA -HSA# 672 | 190 | 93,760 | 202.6 | 170.5 |
| OLMSTED (ROCHESTER), MN-WINONA, MN -HSA# 552 | 1,562 | 899,636 | 173.6 | 148.7 |
