| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| ELK, PA -HSA# 125 | 4 | 104,529 | 3.8 | 3.3 | UNSTABLE |
| TIOGA, PA -HSA# 128 | 4 | 124,489 | 3.2 | 2.6 | UNSTABLE |
| BERKS (READING), PA -HSA# 139 | 29 | 1,061,571 | 2.7 | 2.4 |
| FRANKLIN, PA-WASHINGTON (HAGERSTOWN), MD -HSA# 72 | 21 | 807,803 | 2.6 | 2.3 |
| LYCOMING (WILLIAMSPORT), PA-CLINTON, PA -HSA# 44 | 12 | 465,379 | 2.6 | 2.1 | UNSTABLE |
| ORANGE (NEWBURGH), NY-SULLIVAN, NY -HSA# 86 | 25 | 1,306,642 | 1.9 | 2.1 |
| YORK (YORK), PA-FREDERICK, MD -HSA# 48 | 38 | 1,918,431 | 2.0 | 2.0 |
| MAHONING (YOUNG), OH-MERCER, PA -HSA# 345 | 40 | 1,819,913 | 2.2 | 2.0 |
| PHILADELPHIA (PHILADELPHIA), PA-MONTGOMERY, PA -HSA# 28 | 259 | 11,132,226 | 2.0 | 2.0 |
| SCHUYLKILL, PA-MONTOUR, PA -HSA# 8 | 24 | 1,028,378 | 2.3 | 1.9 |
| LACKAWANNA (SCRANTON), PA-WAYNE, PA -HSA# 47 | 20 | 766,716 | 2.6 | 1.8 | UNSTABLE |
| MIFFLIN, PA-HUNTINGDON, PA -HSA# 110 | 7 | 341,138 | 2.1 | 1.7 | UNSTABLE |
| LEHIGH (ALLE), PA-NORTHAMPTON, PA -HSA# 84 | 41 | 2,210,609 | 1.9 | 1.7 |
| LUZERNE (WILKES-BARRE), PA-COLUMBIA, PA -HSA# 78 | 25 | 1,233,412 | 2.0 | 1.7 |
| CRAWFORD, PA -HSA# 117 | 5 | 267,780 | 1.9 | 1.7 | UNSTABLE |
| VENANGO, PA-CLARION, PA -HSA# 52 | 6 | 314,942 | 1.9 | 1.6 | UNSTABLE |
| WASHINGTON, PA-FAYETTE, PA -HSA# 100 | 24 | 1,178,978 | 2.0 | 1.6 |
| CLEARFIELD, PA-CENTRE ( ), PA -HSA# 26 | 12 | 778,306 | 1.5 | 1.6 | UNSTABLE |
| ALLEGHENY (PITTSBURGH), PA-WESTMORELAND, PA -HSA# 42 | 115 | 6,513,830 | 1.8 | 1.5 |
| LAWRENCE, PA -HSA# 129 | 4 | 285,849 | 1.4 | 1.3 | UNSTABLE |
| ERIE (ERIE), PA-CHAUTAUQUA, NY -HSA# 106 | 18 | 1,388,370 | 1.3 | 1.2 | UNSTABLE |
| CAMBRIA, PA-BLAIR (ALTOONA), PA -HSA# 57 | 17 | 1,253,349 | 1.4 | 1.2 | UNSTABLE |
| DAUPHIN (HARRISBURG), PA-CUMBERLAND, PA -HSA# 43 | 23 | 1,845,131 | 1.2 | 1.2 |
| LANCASTER (LANCASTER), PA -HSA# 140 | 15 | 1,360,658 | 1.1 | 1.0 | UNSTABLE |
| CATTARAUGUS, NY-MC KEAN, PA -HSA# 35 | 6 | 616,999 | 1.0 | 0.9 | UNSTABLE |
| BROOME (BINGHAMTON), NY-BRADFORD, PA -HSA# 19 | 11 | 1,084,256 | 1.0 | 0.9 | UNSTABLE |
