| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| MASON, KY-FLEMING, KY -HSA# 116 | 7 | 115,614 | 6.1 | 5.5 | UNSTABLE |
| ROWAN, KY-MORGAN, KY -HSA# 67 | 6 | 142,745 | 4.2 | 4.0 | UNSTABLE |
| BARREN, KY-MONROE, KY -HSA# 53 | 9 | 221,662 | 4.1 | 4.0 | UNSTABLE |
| BELL, KY-CLAIBORNE, TN -HSA# 96 | 9 | 281,713 | 3.2 | 3.3 | UNSTABLE |
| FLOYD, KY-JOHNSON, KY -HSA# 11 | 7 | 243,698 | 2.9 | 3.2 | UNSTABLE |
| HENDERSON (HENDERSON), KY-UNION, KY -HSA# 40 | 5 | 182,864 | 2.7 | 2.8 | UNSTABLE |
| JEFFERSON (MADISON), IN-DEARBORN, IN -HSA# 321 | 11 | 407,117 | 2.7 | 2.8 | UNSTABLE |
| CABELL (HUNTINGTON), WV-BOYD, KY -HSA# 46 | 30 | 1,094,505 | 2.7 | 2.6 |
| LETCHER, KY -HSA# 123 | 2 | 79,387 | 2.5 | 2.6 | UNSTABLE |
| HOPKINS, KY-CHRISTIAN (HOPKINSVILLE), KY -HSA# 45 | 15 | 604,310 | 2.5 | 2.4 | UNSTABLE |
| FRANKLIN, KY-OWEN, KY -HSA# 114 | 5 | 223,354 | 2.2 | 2.4 | UNSTABLE |
| HARDIN, KY-GRAYSON, KY -HSA# 89 | 10 | 514,370 | 1.9 | 2.2 | UNSTABLE |
| DAVIESS (OWENSBORO), KY-OHIO, KY -HSA# 316 | 10 | 451,822 | 2.2 | 2.2 | UNSTABLE |
| JEFFERSON (LOUISVILLE), KY-SHELBY, KY -HSA# 272 | 61 | 2,664,864 | 2.3 | 2.1 |
| PULASKI, KY-WAYNE, KY -HSA# 37 | 6 | 273,350 | 2.2 | 2.1 | UNSTABLE |
| WHITLEY, KY-LAUREL, KY -HSA# 51 | 8 | 419,585 | 1.9 | 2.1 | UNSTABLE |
| PIKE, KY-LOGAN, WV -HSA# 13 | 8 | 438,885 | 1.8 | 1.9 | UNSTABLE |
| KENTON (COVINGTON), KY-CAMPBELL, KY -HSA# 2 | 15 | 1,049,784 | 1.4 | 1.6 | UNSTABLE |
| FAYETTE (LEXINGTON-FAYETTE), KY-PERRY, KY -HSA# 18 | 19 | 1,413,661 | 1.3 | 1.6 | UNSTABLE |
| MC CRACKEN, KY-GRAVES, KY -HSA# 12 | 10 | 614,053 | 1.6 | 1.3 | UNSTABLE |
| BOURBON (PARIS), KY-NICHOLAS, KY -HSA# 102 | 1 | 78,875 | 1.3 | 1.2 | UNSTABLE |
| SCIOTO, OH-ROSS, OH -HSA# 337 | 7 | 590,297 | 1.2 | 1.1 | UNSTABLE |
| OBION, TN-WEAKLEY, TN -HSA# 181 | 3 | 217,388 | 1.4 | 1.1 | UNSTABLE |
| MADISON, KY-ROCKCASTLE, KY -HSA# 62 | 3 | 328,387 | 0.9 | 1.0 | UNSTABLE |
| CALLOWAY, KY-CARROLL, TN -HSA# 115 | 4 | 323,954 | 1.2 | 1.0 | UNSTABLE |
| TAYLOR, KY-RUSSELL, KY -HSA# 82 | 2 | 198,254 | 1.0 | 0.9 | UNSTABLE |
| WARREN, KY-LOGAN, KY -HSA# 29 | 5 | 503,686 | 1.0 | 0.9 | UNSTABLE |
| BOYLE, KY-LINCOLN, KY -HSA# 27 | 2 | 293,131 | 0.7 | 0.6 | UNSTABLE |
| MONTGOMERY, KY-BATH, KY -HSA# 131 | 0 | 93,350 | 0.0 | 0.0 | UNSTABLE |
| HARRISON, KY-ROBERTSON, KY -HSA# 119 | 0 | 58,485 | 0.0 | 0.0 | UNSTABLE |
| CUMBERLAND, KY-CLINTON, KY -HSA# 104 | 0 | 48,513 | 0.0 | 0.0 | UNSTABLE |
