| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| MARION, IL-WASHINGTON, IL -HSA# 358 | 8 | 172,011 | 4.7 | 4.2 | UNSTABLE |
| JEFFERSON, IL-WAYNE, IL -HSA# 335 | 8 | 168,160 | 4.8 | 4.1 | UNSTABLE |
| SALINE, IL-HARDIN, IL -HSA# 384 | 5 | 128,052 | 3.9 | 4.0 | UNSTABLE |
| VERMILION, IL-EDGAR, IL -HSA# 333 | 15 | 393,455 | 3.8 | 3.4 | UNSTABLE |
| MORGAN, IL-GREENE, IL -HSA# 319 | 6 | 171,364 | 3.5 | 3.2 | UNSTABLE |
| KANKAKEE (KANKAKEE), IL-IROQUOIS, IL -HSA# 343 | 12 | 400,288 | 3.0 | 3.0 | UNSTABLE |
| MACON (DECATUR), IL-SHELBY, IL -HSA# 305 | 17 | 503,483 | 3.4 | 3.0 | UNSTABLE |
| ROCK ISLAND (MOLINE), IL-HENRY, IL -HSA# 307 | 22 | 670,642 | 3.3 | 2.9 |
| VIGO (TERRE HAUTE), IN-SULLIVAN, IN -HSA# 311 | 18 | 610,424 | 2.9 | 2.7 | UNSTABLE |
| COOK (CHICAGO), IL-DU PAGE, IL -HSA# 287 | 568 | 20,683,957 | 2.5 | 2.7 |
| WILLIAMSON, IL-JACKSON, IL -HSA# 331 | 16 | 552,558 | 2.9 | 2.6 | UNSTABLE |
| VANDERBURGH (EVANSVILLE), IN-GIBSON, IN -HSA# 273 | 25 | 932,527 | 2.7 | 2.5 |
| LEE, IA-HANCOCK, IL -HSA# 367 | 6 | 201,973 | 3.0 | 2.4 | UNSTABLE |
| SANGAMON (SPRINGFIELD), IL-MC DONOUGH, IL -HSA# 318 | 27 | 1,003,402 | 2.7 | 2.4 |
| LA SALLE, IL-BUREAU, IL -HSA# 336 | 16 | 573,225 | 2.8 | 2.4 | UNSTABLE |
| ST. CLAIR (BELLEVILLE), IL-RANDOLPH, IL -HSA# 325 | 25 | 1,075,746 | 2.3 | 2.3 |
| DUBUQUE (DUBUQUE), IA-STEPHENSON, IL -HSA# 302 | 14 | 536,666 | 2.6 | 2.3 | UNSTABLE |
| PEORIA (PEORIA), IL-TAZEWELL, IL -HSA# 277 | 27 | 1,138,763 | 2.4 | 2.2 |
| WINNEBAGO (ROCKFORD), IL-LEE, IL -HSA# 291 | 25 | 1,173,086 | 2.1 | 2.1 |
| WHITE, IL-HAMILTON, IL -HSA# 383 | 2 | 72,844 | 2.7 | 1.9 | UNSTABLE |
| WILL (JOLIET), IL-GRUNDY, IL -HSA# 303 | 22 | 1,443,239 | 1.5 | 1.9 |
| MC LEAN (BLOOMINGTON), IL-DE WITT, IL -HSA# 338 | 11 | 580,208 | 1.9 | 1.9 | UNSTABLE |
| DES MOINES, IA-HENRY, IA -HSA# 340 | 4 | 211,988 | 1.9 | 1.6 | UNSTABLE |
| MADISON (ALTON), IL-JERSEY, IL -HSA# 299 | 14 | 905,977 | 1.5 | 1.5 | UNSTABLE |
| KNOX, IL-WARREN, IL -HSA# 324 | 4 | 223,714 | 1.8 | 1.4 | UNSTABLE |
| MC CRACKEN, KY-GRAVES, KY -HSA# 12 | 10 | 614,053 | 1.6 | 1.3 | UNSTABLE |
| CAPE GIRARDEAU, MO-BUTLER, MO -HSA# 563 | 13 | 923,058 | 1.4 | 1.3 | UNSTABLE |
| RICHLAND, IL-CLAY, IL -HSA# 351 | 2 | 146,651 | 1.4 | 1.3 | UNSTABLE |
| KANE (AURORA), IL-DE KALB, IL -HSA# 373 | 17 | 1,548,909 | 1.1 | 1.2 | UNSTABLE |
| MONTGOMERY, IL-MACOUPIN, IL -HSA# 334 | 4 | 240,398 | 1.7 | 1.2 | UNSTABLE |
| CLINTON, IA-WHITESIDE, IL -HSA# 361 | 5 | 381,289 | 1.3 | 1.1 | UNSTABLE |
| KNOX, IN-DAVIESS, IN -HSA# 310 | 5 | 384,332 | 1.3 | 1.1 | UNSTABLE |
| ADAMS, IL-MARION, MO -HSA# 353 | 5 | 443,461 | 1.1 | 1.0 | UNSTABLE |
| CHAMPAIGN (CHAMPAIGN), IL-COLES, IL -HSA# 279 | 8 | 801,910 | 1.0 | 1.0 | UNSTABLE |
| EFFINGHAM, IL-FAYETTE, IL -HSA# 363 | 2 | 165,911 | 1.2 | 0.9 | UNSTABLE |
