| | 1995-97 | Rate/100,000 |
| Name | Deaths | Population | Crude | Age Adjusted |
| TIOGA, PA | 4 | 128,024 | 3.1 | 2.7 |
| VENANGO, PA - CLARION, PA | 10 | 326,827 | 3.1 | 2.6 |
| LYCOMING (WILLIAMSPORT), PA - CLINTON, PA | 13 | 484,915 | 2.7 | 2.3 |
| BERKS (READING), PA | 32 | 1,096,491 | 2.9 | 2.3 |
| FRANKLIN, PA - WASHINGTON (HAGERSTOWN), MD | 19 | 835,762 | 2.3 | 2.0 |
| LACKAWANNA (SCRANTON), PA - WAYNE, PA | 23 | 797,372 | 2.9 | 1.7 |
| ORANGE (NEWBURGH), NY - SULLIVAN, NY | 22 | 1,351,458 | 1.6 | 1.6 |
| ELK, PA | 3 | 108,890 | 2.8 | 1.6 |
| CLEARFIELD, PA - CENTRE (STATE COLLEGE), PA | 12 | 800,574 | 1.5 | 1.6 |
| PHILADELPHIA (PHILADELPHIA), PA - MONTGOMERY, PA | 243 | 11,628,573 | 2.1 | 1.5 |
| WASHINGTON, PA - FAYETTE, PA | 23 | 1,222,306 | 1.9 | 1.5 |
| MAHONING (YOUNG), OH - MERCER, PA | 38 | 1,891,528 | 2.0 | 1.5 |
| YORK (YORK), PA - FREDERICK, MD | 34 | 1,967,062 | 1.7 | 1.4 |
| LAWRENCE, PA | 4 | 297,596 | 1.3 | 1.3 |
| ALLEGHENY (PITTSBURGH), PA - WESTMORELAND, PA | 124 | 6,781,624 | 1.8 | 1.2 |
| MIFFLIN, PA - HUNTINGDON, PA | 5 | 353,969 | 1.4 | 1.2 |
| SCHUYLKILL, PA - MONTOUR, PA | 18 | 1,067,952 | 1.7 | 1.1 |
| ERIE (ERIE), PA - CHAUTAUQUA, NY | 19 | 1,446,893 | 1.3 | 1.1 |
| LUZERNE (WILKES - BARRE), PA - COLUMBIA, PA | 23 | 1,279,871 | 1.8 | 1.1 |
| LEHIGH (ALLE), PA - NORTHAMPTON, PA | 30 | 2,269,818 | 1.3 | 1.0 |
| CRAWFORD, PA | 4 | 277,400 | 1.4 | 1.0 |
| BROOME (BINGHAMTON), NY - BRADFORD, PA | 15 | 1,130,171 | 1.3 | 0.9 |
| CATTARAUGUS, NY - MC KEAN, PA | 5 | 642,636 | 0.8 | 0.8 |
| CAMBRIA, PA - BLAIR (ALTOONA), PA | 13 | 1,299,514 | 1.0 | 0.7 |
| LANCASTER (LANCASTER), PA | 15 | 1,409,935 | 1.1 | 0.7 |
| DAUPHIN (HARRISBURG), PA - CUMBERLAND, PA | 20 | 1,907,087 | 1.0 | 0.7 |
